A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression

Glutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves in the hippocampus region are modulated by histaminergic afferents. Excessive accumulation of glutamate in the synaptic area causes degeneration of neuron cells. The H4 receptor is defined as th...

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Detalles Bibliográficos
Autores principales: Yeni, Yesim, Cakir, Zeynep, Hacimuftuoglu, Ahmet, Taghizadehghalehjoughi, Ali, Okkay, Ufuk, Genc, Sidika, Yildirim, Serkan, Saglam, Yavuz Selim, Calina, Daniela, Tsatsakis, Aristidis, Docea, Anca Oana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880293/
https://www.ncbi.nlm.nih.gov/pubmed/35207733
http://dx.doi.org/10.3390/jpm12020246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880293/
https://www.ncbi.nlm.nih.gov/pubmed/35207733
http://dx.doi.org/10.3390/jpm12020246

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