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A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Role on glutamate Transporter Activity in Chronic Depression
Glutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves in the hippocampus region are modulated by histaminergic afferents. Excessive accumulation of glutamate in the synaptic area causes degeneration of neuron cells. The H4 receptor is defined as th...
Autores principales: | Yeni, Yesim, Cakir, Zeynep, Hacimuftuoglu, Ahmet, Taghizadehghalehjoughi, Ali, Okkay, Ufuk, Genc, Sidika, Yildirim, Serkan, Saglam, Yavuz Selim, Calina, Daniela, Tsatsakis, Aristidis, Docea, Anca Oana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880293/ https://www.ncbi.nlm.nih.gov/pubmed/35207733 http://dx.doi.org/10.3390/jpm12020246 |
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