Design, Synthesis, and Biological Evaluation of a Novel VEGFR-2 Inhibitor Based on a 1,2,5-Oxadiazole-2-Oxide Scaffold with MAPK Signaling Pathway Inhibition

Over the past few decades, the development of broad-spectrum anticancer agents with anti-angiogenic activity has witnessed considerable progress. In this study, a new series of pyrazolo[3,4-d]pyrimidines based on a phenylfuroxan scaffold were designed, synthesized, and evaluated, in terms of their a...

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Detalles Bibliográficos
Autores principales: Mahnashi, Mater H., El-Senduny, Fardous F., Alshahrani, Mohammed Abdulrahman, Abou-Salim, Mahrous A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880564/
https://www.ncbi.nlm.nih.gov/pubmed/35215358
http://dx.doi.org/10.3390/ph15020246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880564/
https://www.ncbi.nlm.nih.gov/pubmed/35215358
http://dx.doi.org/10.3390/ph15020246

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