Human IL-2Rɑ subunit binding modulation of IL-2 through a decline in electrostatic interactions: A computational and experimental approach

Although high-dose IL-2 has clear antitumor effects, severe side effects like severe toxicity and activation of Tregs by binding of IL-2 to high-affinity IL-2R, hypotension, and vascular leak syndrome limit its applications as a therapeutic antitumor agent. Here in this study, a rational computation...

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Detalles Bibliográficos
Autores principales: Beig Parikhani, Arezoo, Bagherzadeh, Kowsar, Dehghan, Rada, Biglari, Alireza, Shokrgozar, Mohammad Ali, Riazi Rad, Farhad, Zeinali, Sirous, Talebkhan, Yeganeh, Ajdary, Soheila, Ahangari Cohan, Reza, Behdani, Mahdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880607/
https://www.ncbi.nlm.nih.gov/pubmed/35213635
http://dx.doi.org/10.1371/journal.pone.0264353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880607/
https://www.ncbi.nlm.nih.gov/pubmed/35213635
http://dx.doi.org/10.1371/journal.pone.0264353

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