Xanthine Oxidase Inhibitor, Febuxostat Is Effective against 5-Fluorouracil-Induced Parotid Salivary Gland Injury in Rats Via Inhibition of Oxidative Stress, Inflammation and Targeting TRPC1/CHOP Signalling Pathway

The current research aimed to examine the ameliorative role of febuxostat (FEB), a highly potent xanthine oxidase inhibitor, against 5-fluorouracil (5-FU)-induced parotid salivary gland damage in rats, as FEB is a pleiotropic drug that has multiple pharmacological effects. A total of 32 Wistar adult...

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Detalles Bibliográficos
Autores principales: Abdelzaher, Walaa Yehia, Nassan, Mohamed A., Ahmed, Sabreen Mahmoud, Welson, Nermeen N., El-Saber Batiha, Gaber, Khalaf, Hanaa Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880727/
https://www.ncbi.nlm.nih.gov/pubmed/35215344
http://dx.doi.org/10.3390/ph15020232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880727/
https://www.ncbi.nlm.nih.gov/pubmed/35215344
http://dx.doi.org/10.3390/ph15020232

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