Cargando…

Unexpected Enhancement of Cytotoxicity of Cisplatin in a Rat Kidney Proximal Tubular Cell Line Overexpressing Mitochondrial Glutathione Transport Activity

In previous studies, we identified the two principal transporters that mediate the uptake of glutathione (GSH) from cytoplasm into the mitochondrial matrix of rat kidney proximal tubular cells. We hypothesized that genetic modulation of transporter expression could markedly alter susceptibility of r...

Descripción completa

Detalles Bibliográficos
Autor principal:	Lash, Lawrence H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880737/ https://www.ncbi.nlm.nih.gov/pubmed/35216119 http://dx.doi.org/10.3390/ijms23041993

Ejemplares similares

Multigenerational Study of Chemically Induced Cytotoxicity and Proliferation in Cultures of Human Proximal Tubular Cells
por: Lash, Lawrence H., et al.
Publicado: (2014)

Mitochondrial Glutathione in Diabetic Nephropathy
por: Lash, Lawrence H.
Publicado: (2015)

Sodium and Water Transport in Kidney Proximal Tubular Cells
por: Whittembury, Guillermo
Publicado: (1968)

Models for coupling of salt and water transport; Proximal tubular reabsorption in Necturus kidney
por: Sackin, H, et al.
Publicado: (1975)

Valproic acid treatment attenuates cisplatin‐induced kidney injury by suppressing proximal tubular cell damage
por: Yoshioka, Toshihiko, et al.
Publicado: (2023)

Effects of Buthionine Sulfoximine Treatment on Cellular Glutathione Levels and Cytotoxicities of Cisplatin, Carboplatin and Radiation in Human Stomach and Ovarian Cancer Cell Lines(*): – Glutathione, Buthionine Sulfoximine, Cytotoxicity –
por: Lee, Kyung Shik, et al.
Publicado: (1992)

Nitro-Arachidonic Acid Prevents Angiotensin II-Induced Mitochondrial Dysfunction in a Cell Line of Kidney Proximal Tubular Cells
por: Sánchez-Calvo, Beatriz, et al.
Publicado: (2016)

Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury
por: Mizuno, Tomohiro, et al.
Publicado: (2015)

Cisplatin induces primary necrosis through poly(ADP-ribose) polymerase 1 activation in kidney proximal tubular cells
por: Park, Seulgee, et al.
Publicado: (2015)

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells
por: Liu, Jing, et al.
Publicado: (2018)

Panduratin A Derivative Protects against Cisplatin-Induced Apoptosis of Renal Proximal Tubular Cells and Kidney Injury in Mice
por: Thongnuanjan, Penjai, et al.
Publicado: (2021)

Canagliflozin protects against cisplatin-induced acute kidney injury by AMPK-mediated autophagy in renal proximal tubular cells
por: Park, Cheol Ho, et al.
Publicado: (2022)

Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines
por: Okuno, S, et al.
Publicado: (2003)

Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury [Corrigendum]
Publicado: (2017)

Relationship between PPARα activation and NO on proximal tubular Na(+ )transport in the rat
por: Newaz, Mohammad A, et al.
Publicado: (2004)

Assessment of kidney proximal tubular secretion in critical illness
por: Bhatraju, Pavan K., et al.
Publicado: (2021)

Effect of Suramin on Renal Proximal Tubular Cells Damage Induced by Cisplatin in Rats (Histological and Immunohistochemical Study)
por: El-Kordy, Eman Ali
Publicado: (2019)

Effects of Nitric Oxide on Renal Proximal Tubular Na(+) Transport
por: Satoh, Nobuhiko, et al.
Publicado: (2017)

Glutathione Levels and Susceptibility to Chemically Induced Injury in Two Human Prostate Cancer Cell Lines
por: Lash, Lawrence H., et al.
Publicado: (2015)

Early detection of acute cisplatin nephrotoxicity: interest of urinary monitoring of proximal tubular biomarkers
por: Bunel, Valérian, et al.
Publicado: (2017)

Mitochondrial Dynamics of Proximal Tubular Epithelial Cells in Nephropathic Cystinosis
por: De Rasmo, Domenico, et al.
Publicado: (2019)

Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis
por: Eymael, Jennifer, et al.
Publicado: (2022)

Glucose-Induced Down Regulation of Thiamine Transporters in the Kidney Proximal Tubular Epithelium Produces Thiamine Insufficiency in Diabetes
por: Larkin, James R., et al.
Publicado: (2012)

Proximal tubular transport of Metallothionein-Mercury complexes and protection against nephrotoxicity
por: Dave, Aditi, et al.
Publicado: (2023)

Correction: Nitro-Arachidonic Acid Prevents Angiotensin II Induced Mitochondrial Dysfunction in Kidney Proximal Tubular Cells
por: Sánchez-Calvo, Beatriz, et al.
Publicado: (2016)

Regulation of Cisplatin Cytotoxicity by Cu Influx Transporters
por: Abada, Paolo, et al.
Publicado: (2010)

Species Diversity Regarding the Presence of Proximal Tubular Progenitor Cells of the Kidney
por: Hansson, J., et al.
Publicado: (2016)

Proximal Tubular Secretion: A New Way to Assess for Kidney Dysfunction?
por: Au, Eric H.K., et al.
Publicado: (2022)

Proximal Tubular Deposits and an Abnormal MRI of the Kidneys with Chronic Hemolytic Anemia
por: Toishi, Takumi, et al.
Publicado: (2023)

In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells
por: Kurosaki, Yoshifumi, et al.
Publicado: (2022)

Protective Effect of Quercetin 3-O-Glucuronide against Cisplatin Cytotoxicity in Renal Tubular Cells
por: Muñoz-Reyes, Daniel, et al.
Publicado: (2022)

Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells
por: Huang, Johnny X, et al.
Publicado: (2015)

Distinct Mitochondrial Pathologies Caused by Mutations of the Proximal Tubular Enzymes EHHADH and GATM
por: Forst, Anna-Lena, et al.
Publicado: (2021)

Proximal Tubular Hypertrophy and Enlarged Glomerular and Proximal Tubular Urinary Space in Obese Subjects with Proteinuria
por: Tobar, Ana, et al.
Publicado: (2013)

Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca(2+) signaling in SKOV3 cells
por: Xu, Lu, et al.
Publicado: (2018)

Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines.
por: Welters, M. J., et al.
Publicado: (1998)

Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis
por: Lu, Qingmiao, et al.
Publicado: (2020)

Metabolomic Changes of Human Proximal Tubular Cell Line in High Glucose Environment
por: Wei, Pascal Zhongping, et al.
Publicado: (2019)

Hymenialdisine is Cytotoxic Against Cisplatin-Sensitive but Not Against Cisplatin-Resistant Cell Lines
por: Abdullah, Nada, et al.
Publicado: (2021)

Deletion of NADPH oxidase 2 attenuates cisplatin-induced acute kidney injury through reducing ROS-induced proximal tubular cell injury and inflammation
por: Chen, Ho-Ching, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_icmfrtsncsr52ohus3q0eh7oe7