The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation

T cells defend against cancer and viral infections by rapidly scanning the surface of target cells seeking specific peptide antigens. This key process in adaptive immunity is sparked upon T cell receptor (TCR) binding of antigens within cell-cell junctions stabilized by integrin (LFA-1)/intercellula...

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Detalles Bibliográficos
Autores principales: Ma, Victor Pui-Yan, Hu, Yuesong, Kellner, Anna V., Brockman, Joshua M., Velusamy, Arventh, Blanchard, Aaron T., Evavold, Brian D., Alon, Ronen, Salaita, Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880789/
https://www.ncbi.nlm.nih.gov/pubmed/35213231
http://dx.doi.org/10.1126/sciadv.abg4485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880789/
https://www.ncbi.nlm.nih.gov/pubmed/35213231
http://dx.doi.org/10.1126/sciadv.abg4485

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