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The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation

T cells defend against cancer and viral infections by rapidly scanning the surface of target cells seeking specific peptide antigens. This key process in adaptive immunity is sparked upon T cell receptor (TCR) binding of antigens within cell-cell junctions stabilized by integrin (LFA-1)/intercellula...

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Detalles Bibliográficos
Autores principales:	Ma, Victor Pui-Yan, Hu, Yuesong, Kellner, Anna V., Brockman, Joshua M., Velusamy, Arventh, Blanchard, Aaron T., Evavold, Brian D., Alon, Ronen, Salaita, Khalid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880789/ https://www.ncbi.nlm.nih.gov/pubmed/35213231 http://dx.doi.org/10.1126/sciadv.abg4485

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