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Proteasome inhibition-enhanced fracture repair is associated with increased mesenchymal progenitor cells in mice
The ubiquitin/proteasome system controls the stability of Runx2 and JunB, proteins essential for differentiation of mesenchymal progenitor/stem cells (MPCs) to osteoblasts. Local administration of proteasome inhibitor enhances bone fracture healing by accelerating endochondral ossification. However,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880819/ https://www.ncbi.nlm.nih.gov/pubmed/35213543 http://dx.doi.org/10.1371/journal.pone.0263839 |