Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1

Primary ciliary defects cause a group of developmental conditions known as ciliopathies. Here, we provide mechanistic insight into ciliary ubiquitin processing in cells and for mouse model lacking the ciliary protein Mks1. In vivo loss of Mks1 sensitises cells to proteasomal disruption, leading to a...

Descripción completa

Detalles Bibliográficos
Autores principales: Szymanska, Katarzyna, Boldt, Karsten, Logan, Clare V, Adams, Matthew, Robinson, Philip A, Ueffing, Marius, Zeqiraj, Elton, Wheway, Gabrielle, Johnson, Colin A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880992/
https://www.ncbi.nlm.nih.gov/pubmed/35170427
http://dx.doi.org/10.7554/eLife.57593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880992/
https://www.ncbi.nlm.nih.gov/pubmed/35170427
http://dx.doi.org/10.7554/eLife.57593

Ejemplares similares