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Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish

Aging individuals exhibit a pervasive decline in adaptive immune function, with important implications for health and lifespan. Previous studies have found a pervasive loss of immune-repertoire diversity in human peripheral blood during aging; however, little is known about repertoire aging in other...

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Detalles Bibliográficos
Autores principales: Bradshaw, William John, Poeschla, Michael, Placzek, Aleksandra, Kean, Samuel, Valenzano, Dario Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880994/
https://www.ncbi.nlm.nih.gov/pubmed/35129436
http://dx.doi.org/10.7554/eLife.65117