Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity

Developmental trajectories of gene expression may reverse in their direction during ageing, a phenomenon previously linked to cellular identity loss. Our analysis of cerebral cortex, lung, liver, and muscle transcriptomes of 16 mice, covering development and ageing intervals, revealed widespread but...

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Detalles Bibliográficos
Autores principales: Izgi, Hamit, Han, Dingding, Isildak, Ulas, Huang, Shuyun, Kocabiyik, Ece, Khaitovich, Philipp, Somel, Mehmet, Dönertaş, Handan Melike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880995/
https://www.ncbi.nlm.nih.gov/pubmed/35098922
http://dx.doi.org/10.7554/eLife.68048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880995/
https://www.ncbi.nlm.nih.gov/pubmed/35098922
http://dx.doi.org/10.7554/eLife.68048

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