The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes

The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects on mammalian cells, proteolytically activated C2II (C2IIa) forms barrel-shaped heptamers that bind to carbohydrate r...

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Detalles Bibliográficos
Autores principales: Eisele, Julia, Schreiner, Simone, Borho, Joscha, Fischer, Stephan, Heber, Sebastian, Endres, Sascha, Fellermann, Maximilian, Wohlgemuth, Lisa, Huber-Lang, Markus, Fois, Giorgio, Fauler, Michael, Frick, Manfred, Barth, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881014/
https://www.ncbi.nlm.nih.gov/pubmed/35222028
http://dx.doi.org/10.3389/fphar.2022.810611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881014/
https://www.ncbi.nlm.nih.gov/pubmed/35222028
http://dx.doi.org/10.3389/fphar.2022.810611

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