Cargando…

Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling

BACKGROUND: Whole genome doubling is a frequent event during cancer evolution and shapes the cancer genome due to the occurrence of chromosomal instability. Yet, erroneously arising human tetraploid cells usually do not proliferate due to p53 activation that leads to CDKN1A expression, cell cycle ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bernhard, Sara Vanessa, Seget-Trzensiok, Katarzyna, Kuffer, Christian, Krastev, Dragomir B., Stautmeister, Lisa-Marie, Theis, Mirko, Keuper, Kristina, Boekenkamp, Jan-Eric, Kschischo, Maik, Buchholz, Frank, Storchova, Zuzana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881269/ https://www.ncbi.nlm.nih.gov/pubmed/34962618 http://dx.doi.org/10.1007/s13402-021-00654-5

Ejemplares similares

The p53/p73 - p21(CIP1) tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells
por: Schmidt, Ann-Kathrin, et al.
Publicado: (2020)

Decreased expression of SPINT1-AS1 and SPINT1 mRNA might be independent unfavorable prognostic indicators in esophageal squamous cell carcinoma
por: Shen, Fang-Fang, et al.
Publicado: (2019)

Elevated Circulating and Placental SPINT2 Is Associated with Placental Dysfunction
por: Murphy, Ciara N., et al.
Publicado: (2021)

Aberrant methylation and silencing of the SPINT2 gene in high‐grade gliomas
por: Fukushima, Tsuyoshi, et al.
Publicado: (2018)

SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses
por: Straus, Marco R., et al.
Publicado: (2020)

Comprehensive Analysis of the Expression and Prognostic Value of SPINT1/2 in Breast Carcinoma
por: Wu, Qiulin, et al.
Publicado: (2021)

Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity
por: Gersch, Malte, et al.
Publicado: (2019)

Mitotic Spindle Orients Perpendicular to the Forces Imposed by Dynamic Shear
por: Fernandez, Pablo, et al.
Publicado: (2011)

Targeting deubiquitinase USP28 for cancer therapy
por: Wang, Xiaofang, et al.
Publicado: (2018)

Fbw7 and Usp28 – enemies and allies
por: Taranets, Lyudmyla, et al.
Publicado: (2015)

Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25
por: Valero, Rebeca, et al.
Publicado: (2001)

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction
por: Kaitu’u-Lino, Tu’uhevaha J., et al.
Publicado: (2020)

Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction
por: Murphy, Ciara N., et al.
Publicado: (2022)

Systems approaches identify the consequences of monosomy in somatic human cells
por: Chunduri, Narendra Kumar, et al.
Publicado: (2021)

Searching for Errors in Models of Complex Dynamic Systems
por: Kahl, Dominik, et al.
Publicado: (2021)

MFmap: A semi-supervised generative model matching cell lines to tumours and cancer subtypes
por: Zhang, Xiaoxiao, et al.
Publicado: (2021)

Distinct and Common Features of Numerical and Structural Chromosomal Instability across Different Cancer Types
por: Zhang, Xiaoxiao, et al.
Publicado: (2022)

LncRNAs GIHCG and SPINT1-AS1 Are Crucial Factors for Pan-Cancer Cells Sensitivity to Lapatinib
por: Xiang, Zhen, et al.
Publicado: (2019)

SPINT1-AS1 Drives Cervical Cancer Progression via Repressing miR-214 Biogenesis
por: Song, Hongjuan, et al.
Publicado: (2021)

Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28
por: Toth, Rachel K., et al.
Publicado: (2022)

Functional Analysis of a Missense Mutation in the Serine Protease Inhibitor SPINT2 Associated with Congenital Sodium Diarrhea
por: Faller, Nicolas, et al.
Publicado: (2014)

Epigenetic Silencing of SPINT2 promotes Cancer Cell Motility via HGF-MET Pathway Activation in Melanoma
por: Hwang, Soonyean, et al.
Publicado: (2015)

Learning (from) the errors of a systems biology model
por: Engelhardt, Benjamin, et al.
Publicado: (2016)

A Bayesian approach to estimating hidden variables as well as missing and wrong molecular interactions in ordinary differential equation-based mathematical models
por: Engelhardt, Benjamin, et al.
Publicado: (2017)

Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment
por: Gómez-Abenza, Elena, et al.
Publicado: (2019)

Exosome‐delivered miR‐221/222 exacerbates tumor liver metastasis by targeting SPINT1 in colorectal cancer
por: Tian, Fei, et al.
Publicado: (2021)

Genetic instability from a single S phase after whole-genome duplication
por: Gemble, Simon, et al.
Publicado: (2022)

Author Correction: Genetic instability from a single S phase after whole-genome duplication
por: Gemble, Simon, et al.
Publicado: (2022)

Isolated choanal and gut atresias: pathogenetic role of serine protease inhibitor type 2 (SPINT2) gene mutations unlikely
por: Niederwanger, Christian, et al.
Publicado: (2018)

Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the Apc(Min/+) model
por: Kawaguchi, Makiko, et al.
Publicado: (2016)

The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity
por: Ramirez Alvarez, Carlos, et al.
Publicado: (2021)

SPINT2 is involved in the proliferation, migration and phenotypic switching of aortic smooth muscle cells: Implications for the pathogenesis of thoracic aortic dissection
por: Li, Jun, et al.
Publicado: (2023)

Evolution of aneuploidy: overcoming the original CIN
por: Storchova, Zuzana
Publicado: (2018)

The adaptive strategies of cells in the face of CIN
por: Storchová, Zuzana
Publicado: (2023)

Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies
por: Saei, Azad, et al.
Publicado: (2018)

USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma
por: Prieto-Garcia, Cristian, et al.
Publicado: (2021)

The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells
por: Li, Junjun, et al.
Publicado: (2023)

STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer
por: Ma, Zhiqiang, et al.
Publicado: (2019)

Germline ancestry influences the evolutionary disease course in lung adenocarcinomas
por: Schenk, Alina, et al.
Publicado: (2020)

Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer’s Disease and Amnestic Mild Cognitive Impairment
por: Kobayashi, Nobuyuki, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_eh2po27q1m6n06f6n2aalhmff3