Integrated approach to functional analysis of an ERBB2 variant of unknown significance detected by a cancer gene panel test

PURPOSE: Dealing with variants of unknown significance (VUS) is an important issue in the clinical application of NGS-based cancer gene panel tests. We detected a novel ERBB2 extracellular domain VUS, c.1157A > G p.(E401G), in a cancer gene panel test. Since the mechanisms of activation by ERBB2...

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Detalles Bibliográficos
Autores principales: Harada, Yohei, Sato, Akemi, Araki, Mitsugu, Matsumoto, Shigeyuki, Isaka, Yuta, Sagae, Yukari, Abe, Tomonori, Aoyagi, Yasuko, Sueoka, Eisaburo, Okuno, Yasushi, Kimura, Shinya, Sueoka-Aragane, Naoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881279/
https://www.ncbi.nlm.nih.gov/pubmed/34997908
http://dx.doi.org/10.1007/s13402-021-00656-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881279/
https://www.ncbi.nlm.nih.gov/pubmed/34997908
http://dx.doi.org/10.1007/s13402-021-00656-3

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