Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration

The circadian clock participates in maintaining homeostasis in peripheral tissues, including intervertebral discs (IVDs). Abnormal mechanical loading is a known risk factor for intervertebral disc degeneration (IDD). Based on the rhythmic daily loading pattern of rest and activity, we hypothesized t...

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Detalles Bibliográficos
Autores principales: Wang, Dong, Peng, Pandi, Dudek, Michal, Hu, Xueyu, Xu, Xiaolong, Shang, Qiliang, Wang, Di, Jia, Haoruo, Wang, Han, Gao, Bo, Zheng, Chao, Mao, Jianxin, Gao, Chu, He, Xin, Cheng, Pengzhen, Wang, Huanbo, Zheng, Jianmin, Hoyland, Judith A., Meng, Qing-Jun, Luo, Zhuojing, Yang, Liu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881495/
https://www.ncbi.nlm.nih.gov/pubmed/35217644
http://dx.doi.org/10.1038/s41413-022-00187-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881495/
https://www.ncbi.nlm.nih.gov/pubmed/35217644
http://dx.doi.org/10.1038/s41413-022-00187-z

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