Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay

SARS-CoV-2 proteases Mpro and PLpro are promising targets for antiviral drug development. In this study, we present an antiviral screening strategy involving a novel in-cell protease assay, antiviral and biochemical activity assessments, as well as structural determinations for rapid identification...

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Detalles Bibliográficos
Autores principales: Narayanan, Anoop, Narwal, Manju, Majowicz, Sydney A., Varricchio, Carmine, Toner, Shay A., Ballatore, Carlo, Brancale, Andrea, Murakami, Katsuhiko S., Jose, Joyce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881501/
https://www.ncbi.nlm.nih.gov/pubmed/35217718
http://dx.doi.org/10.1038/s42003-022-03090-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881501/
https://www.ncbi.nlm.nih.gov/pubmed/35217718
http://dx.doi.org/10.1038/s42003-022-03090-9

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