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Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay
SARS-CoV-2 proteases Mpro and PLpro are promising targets for antiviral drug development. In this study, we present an antiviral screening strategy involving a novel in-cell protease assay, antiviral and biochemical activity assessments, as well as structural determinations for rapid identification...
Autores principales: | Narayanan, Anoop, Narwal, Manju, Majowicz, Sydney A., Varricchio, Carmine, Toner, Shay A., Ballatore, Carlo, Brancale, Andrea, Murakami, Katsuhiko S., Jose, Joyce |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881501/ https://www.ncbi.nlm.nih.gov/pubmed/35217718 http://dx.doi.org/10.1038/s42003-022-03090-9 |
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