A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6

The coordinated action of multiple replicative helicase loading factors is needed for the licensing of replication origins prior to DNA replication. Binding of the Origin Recognition Complex (ORC) to DNA initiates the ATP-dependent recruitment of Cdc6, Cdt1 and Mcm2-7 loading, but the structural det...

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Detalles Bibliográficos
Autores principales: Schmidt, Jan Marten, Yang, Ran, Kumar, Ashish, Hunker, Olivia, Seebacher, Jan, Bleichert, Franziska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881611/
https://www.ncbi.nlm.nih.gov/pubmed/35217664
http://dx.doi.org/10.1038/s41467-022-28695-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881611/
https://www.ncbi.nlm.nih.gov/pubmed/35217664
http://dx.doi.org/10.1038/s41467-022-28695-w

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