Cargando…

A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6

The coordinated action of multiple replicative helicase loading factors is needed for the licensing of replication origins prior to DNA replication. Binding of the Origin Recognition Complex (ORC) to DNA initiates the ATP-dependent recruitment of Cdc6, Cdt1 and Mcm2-7 loading, but the structural det...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmidt, Jan Marten, Yang, Ran, Kumar, Ashish, Hunker, Olivia, Seebacher, Jan, Bleichert, Franziska
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881611/ https://www.ncbi.nlm.nih.gov/pubmed/35217664 http://dx.doi.org/10.1038/s41467-022-28695-w

Ejemplares similares

Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6
por: Schmidt, Jan Marten, et al.
Publicado: (2020)

The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6
por: Feng, Xiang, et al.
Publicado: (2021)

Yeast ORC sumoylation status fine-tunes origin licensing
por: Regan-Mochrie, Gemma, et al.
Publicado: (2022)

Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae
por: Philip, Jasmin, et al.
Publicado: (2022)

Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6
por: Yuan, Zuanning, et al.
Publicado: (2020)

Changing protein-DNA interactions promote ORC binding site exchange during replication origin licensing
por: Zhang, Annie, et al.
Publicado: (2023)

Changing protein–DNA interactions promote ORC binding-site exchange during replication origin licensing
por: Zhang, Annie, et al.
Publicado: (2023)

Diversity and evolution of multiple orc/cdc6-adjacent replication origins in haloarchaea
por: Wu, Zhenfang, et al.
Publicado: (2012)

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation
por: Bleichert, Franziska, et al.
Publicado: (2013)

Origins of DNA replication
por: Ekundayo, Babatunde, et al.
Publicado: (2019)

Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2–7 ring closing
por: Amasino, Audra, et al.
Publicado: (2023)

Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing
por: Amasino, Audra L., et al.
Publicado: (2023)

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines
por: Gardner, Nicola J., et al.
Publicado: (2017)

Potential Prognostic and Diagnostic Values of CDC6, CDC45, ORC6 and SNHG7 in Colorectal Cancer
por: Hu, Yang, et al.
Publicado: (2019)

Identification of ORC1/CDC6-Interacting Factors in Trypanosoma brucei Reveals Critical Features of Origin Recognition Complex Architecture
por: Tiengwe, Calvin, et al.
Publicado: (2012)

An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing
por: Amin, Aftab, et al.
Publicado: (2023)

Cdc6 licenses tumor growth
por: Leslie, Mitch
Publicado: (2011)

An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea
por: Sun, Mengmeng, et al.
Publicado: (2018)

Proteins of the origin recognition complex (ORC) and DNA topoisomerases on mammalian chromatin
por: Hu, Hong-gang, et al.
Publicado: (2009)

Genomewide and biochemical analyses of DNA-binding activity of Cdc6/Orc1 and Mcm proteins in Pyrococcus sp.
por: Matsunaga, Fujihiko, et al.
Publicado: (2007)

RNAP-II Molecules Participate in the Anchoring of the ORC to rDNA Replication Origins
por: Mayan, Maria D.
Publicado: (2013)

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
por: Coulombe, Philippe, et al.
Publicado: (2019)

Molecular determinants of origin discrimination by Orc1 initiators in archaea
por: Dueber, Erin C., et al.
Publicado: (2011)

ORC1 BAH domain links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome
por: Kuo, Alex J., et al.
Publicado: (2012)

Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
por: Bai, Lin, et al.
Publicado: (2019)

Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription
por: Hossain, Manzar, et al.
Publicado: (2016)

Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1
por: Yuan, Zuanning, et al.
Publicado: (2017)

Interaction of the Retinoblastoma Protein with Orc1 and Its Recruitment to Human Origins of DNA Replication
por: Mendoza-Maldonado, Ramiro, et al.
Publicado: (2010)

DNA sequence templates adjacent nucleosome and ORC sites at gene amplification origins in Drosophila
por: Liu, Jun, et al.
Publicado: (2015)

Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA
por: Xu, Naining, et al.
Publicado: (2020)

The remarkable gymnastics of ORC
por: Stillman, Bruce
Publicado: (2022)

The ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loading
por: Riera, Alberto, et al.
Publicado: (2013)

Rethinking origin licensing
por: Bell, Stephen P
Publicado: (2017)

Specific binding of eukaryotic ORC to DNA replication origins depends on highly conserved basic residues
por: Kawakami, Hironori, et al.
Publicado: (2015)

ORC1 binds to cis-transcribed RNAs for efficient activation of replication origins
por: Mas, Aina Maria, et al.
Publicado: (2023)

Crystal Structure of the Eukaryotic Origin Recognition Complex
por: Bleichert, Franziska, et al.
Publicado: (2015)

A Link between ORC-Origin Binding Mechanisms and Origin Activation Time Revealed in Budding Yeast
por: Hoggard, Timothy, et al.
Publicado: (2013)

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA
por: Sun, Jingchuan, et al.
Publicado: (2013)

The spatial arrangement of ORC binding modules determines the functionality of replication origins in budding yeast
por: Bolon, Yung-Tsi, et al.
Publicado: (2006)

A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint
por: Sánchez, Humberto, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_osvn7pcsc5qqq4o8i854ge7b5b