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Engineering miRNA features into siRNAs: Guide-strand bulges are compatible with gene repression
Synthetic siRNA guide strands are typically designed with perfect complementarity to the passenger strand and the target mRNA. We examined whether siRNAs with intentional guide-strand bulges are functional in vitro and in vivo. Importantly, this was done by systematic shortening of the passenger str...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881630/ https://www.ncbi.nlm.nih.gov/pubmed/35251767 http://dx.doi.org/10.1016/j.omtn.2022.02.004 |