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The dual role of p62 in ferroptosis of glioblastoma according to p53 status

BACKGROUND: Ferroptosis plays a key role in human cancer, but its function and mechanism in glioma is not clear. P62/SQSTM1 was reported to inhibit ferroptosis via the activation of NRF2 signaling pathway. In this study we reveal a dual role of p62 in ferroptosis of glioblastoma (GBM) according to p...

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Detalles Bibliográficos
Autores principales: Yuan, Fanen, Sun, Qian, Zhang, Si, Ye, Liguo, Xu, Yang, Deng, Gang, Xu, Zhou, Zhang, Shenqi, Liu, Baohui, Chen, Qianxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881833/
https://www.ncbi.nlm.nih.gov/pubmed/35216629
http://dx.doi.org/10.1186/s13578-022-00764-z