Cargando…
p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function
Alzheimer’s disease (AD) and other tauopathies are histopathologically characterized by tau aggregation, along with a chronic inflammatory response driven by microglia. Over the past few years, the role of microglia in AD has been studied mainly in relation to amyloid-β (Aβ) pathology. Consequently,...
Autores principales: | Perea, Juan R., Bolós, Marta, Cuadros, Raquel, García, Esther, García-Escudero, Vega, Hernández, Félix, McManus, Róisín M., Heneka, Michael T., Avila, Jesús |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882095/ https://www.ncbi.nlm.nih.gov/pubmed/35006531 http://dx.doi.org/10.1007/s12035-021-02715-0 |
Ejemplares similares
-
p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
por: Perea, Juan R., et al.
Publicado: (2022) -
Microglia in Alzheimer’s Disease in the Context of Tau Pathology
por: Perea, Juan Ramón, et al.
Publicado: (2020) -
The Role of Microglia in the Spread of Tau: Relevance for Tauopathies
por: Perea, Juan R., et al.
Publicado: (2018) -
A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer’s disease
por: García-Escudero, Vega, et al.
Publicado: (2021) -
Absence of CX3CR1 impairs the internalization of Tau by microglia
por: Bolós, Marta, et al.
Publicado: (2017)