TREX1 Deficiency Induces ER Stress-Mediated Neuronal Cell Death by Disrupting Ca(2+) Homeostasis

TREX1 is an exonuclease that degrades extranuclear DNA species in mammalian cells. Herein, we show a novel mechanism by which TREX1 interacts with the BiP/GRP78 and TREX1 deficiency triggers ER stress through the accumulation of single-stranded DNA and activates unfolded protein response (UPR) signa...

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Detalles Bibliográficos
Autores principales: Halder, Debasish, Jeon, Su-Jin, Yoon, Ji-Yong, Lee, Jeong-Ju, Jun, Soo Young, Choi, Min-Hyuk, Jeong, Bohyeon, Sung, Duk Hyun, Lee, Da Yong, Kim, Byoung Joon, Kim, Nam-Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882114/
https://www.ncbi.nlm.nih.gov/pubmed/34997539
http://dx.doi.org/10.1007/s12035-021-02631-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882114/
https://www.ncbi.nlm.nih.gov/pubmed/34997539
http://dx.doi.org/10.1007/s12035-021-02631-3

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