A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease

BACKGROUND: Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of the CAG repeat in the huntingtin (HTT) gene. When the number of CAG repeats exceeds 36, the translated expanded polyglutamine-containing HTT protein (mutant HTT [mHTT]) interferes with the normal functio...

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Detalles Bibliográficos
Autores principales: Chen, Kai-Po, Hua, Kuo-Feng, Tsai, Fu-Ting, Lin, Ting-Yu, Cheng, Chih-Yuan, Yang, Ding-I., Hsu, Hsien-Ta, Ju, Tz-Chuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882273/
https://www.ncbi.nlm.nih.gov/pubmed/35219323
http://dx.doi.org/10.1186/s12974-022-02419-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882273/
https://www.ncbi.nlm.nih.gov/pubmed/35219323
http://dx.doi.org/10.1186/s12974-022-02419-9

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