Tricyclic Antidepressant Structure-Related Alterations in Calcium-Dependent Inhibition and Open-Channel Block of NMDA Receptors

N-methyl-D-aspartate receptors (NMDARs) are an essential target for the analgetic action of tricyclic antidepressants (TCAs). Their therapeutic blood concentrations achieve 0.5–1.5 μM, which, however, are insufficient to cause in vitro the open-channel block known as the only effect of TCAs on NMDAR...

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Detalles Bibliográficos
Autores principales: Stepanenko, Yulia D., Sibarov, Dmitry A., Shestakova, Natalia N., Antonov, Sergei M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882908/
https://www.ncbi.nlm.nih.gov/pubmed/35237149
http://dx.doi.org/10.3389/fphar.2021.815368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882908/
https://www.ncbi.nlm.nih.gov/pubmed/35237149
http://dx.doi.org/10.3389/fphar.2021.815368

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