Cargando…

Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque

Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 has rapidly expanded into a serious global pandemic. Due to the high morbidity and mortality of COVID-19, there is an urgent need to develop safe and effective vaccines. AdC68-1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dai, Xuedong, Zhao, Weijun, Tong, Xin, Liu, Wei, Zeng, Xianhuan, Duan, Xiaohui, Wu, Hua, Wang, Lili, Huang, Zhen, Tang, Xinying, Yang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Immunotoxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883008/ https://www.ncbi.nlm.nih.gov/pubmed/35226134 http://dx.doi.org/10.1007/s00204-021-03221-x

Ejemplares similares

rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits
por: Rosner, Amir, et al.
Publicado: (2022)

Preliminary nonclinical safety and immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs
por: Madar-Balakirski, Noa, et al.
Publicado: (2022)

Targets and Intracellular Signaling Mechanisms for Deoxynivalenol-Induced Ribosomal RNA Cleavage
por: He, Kaiyu, et al.
Publicado: (2012)

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha
por: Lu, Jingtao, et al.
Publicado: (2012)

Immunological impact of graphene oxide sheets in the abdominal cavity is governed by surface reactivity
por: Rodrigues, Artur Filipe, et al.
Publicado: (2018)

An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac
por: Selvaraj, Saravanakumar, et al.
Publicado: (2020)

The GARDpotency Assay for Potency-Associated Subclassification of Chemical Skin Sensitizers—Rationale, Method Development, and Ring Trial Results of Predictive Performance and Reproducibility
por: Gradin, Robin, et al.
Publicado: (2020)

Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells
por: Chen, I-Ling, et al.
Publicado: (2020)

Characterization of the Class I MHC Peptidome Resulting From DNCB Exposure of HaCaT Cells
por: Bailey, Alistair, et al.
Publicado: (2020)

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
por: Ogese, Monday O, et al.
Publicado: (2021)

Mouse innate-like B-1 lymphocytes promote inhaled particle-induced in vitro granuloma formation and inflammation in conjunction with macrophages
por: Hiéronimus, Léa, et al.
Publicado: (2021)

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity
por: Hammond, Sean, et al.
Publicado: (2021)

Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis
por: Sernoskie, Samantha Christine, et al.
Publicado: (2021)

Electronic cigarette vapor exposure exaggerates the pro-inflammatory response during influenza A viral infection in human distal airway epithelium
por: Schaunaman, Niccolette, et al.
Publicado: (2022)

Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case–control study
por: Nakajima, Tamie, et al.
Publicado: (2022)

Influence of deoxynivalenol-contaminated feed on the immune response of pigs after PRRSV vaccination and infection
por: Pierron, Alix, et al.
Publicado: (2023)

Quantifying the impact of PFOA exposure on B-cell development and antibody production
por: Taylor, Krystal D, et al.
Publicado: (2023)

Role of miR-24-3p and miR-146a-5p in dendritic cells’ maturation process induced by contact sensitizers
por: Galbiati, Valentina, et al.
Publicado: (2023)

Development of an in chemico high-throughput screening method for the identification of skin sensitization potential
por: Ferreira, Isabel, et al.
Publicado: (2023)

Applicability of the DPRA on mixture testing: challenges and opportunities
por: Marcelis, Quinten, et al.
Publicado: (2023)

Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
por: Ali, Serat-E, et al.
Publicado: (2023)

Correlates of Protection Against SIV(mac251) Infection in Rhesus Macaques Immunized With Chimpanzee-Derived Adenovirus Vectors
por: Tuyishime, Steven, et al.
Publicado: (2018)

Evaluation of heterologous prime-boost vaccination strategies using chimpanzee adenovirus and modified vaccinia virus for TB subunit vaccination in rhesus macaques
por: Vierboom, Michel P. M., et al.
Publicado: (2020)

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques
por: Hassan, Ahmed O., et al.
Publicado: (2021)

P19-35. Replicating adenovirus type 5 host range recombinant vaccine biodistribution in rhesus macaques following multiple mucosal routes of immunization
por: Patterson, J, et al.
Publicado: (2009)

Commentary. Looking back
por: Eisen, Herman N.
Publicado: (1989)

Adenoviruses in Fecal Samples from Asymptomatic Rhesus Macaques, United States
por: Roy, Soumitra, et al.
Publicado: (2012)

GC-biased gene conversion in X-chromosome palindromes conserved in human, chimpanzee, and rhesus macaque
por: Jackson, Emily K, et al.
Publicado: (2021)

Connectional asymmetry of the inferior parietal lobule shapes hemispheric specialization in humans, chimpanzees, and rhesus macaques
por: Cheng, Luqi, et al.
Publicado: (2021)

Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies
por: Silva Lima, Beatriz, et al.
Publicado: (2018)

A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
por: Lee, Sujin, et al.
Publicado: (2016)

Immunogenicity and efficacy of a chimpanzee adenovirus-vectored Rift Valley Fever vaccine in mice
por: Warimwe, George M, et al.
Publicado: (2013)

Biodistribution of neutralizing monoclonal antibodies IgG1 b12 and LALA in mucosal and lymphatic tissues of rhesus macaques
por: Hessell, AJ, et al.
Publicado: (2012)

An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs
por: Awasthi, Sita, et al.
Publicado: (2017)

Toxicology, biodistribution and shedding profile of a recombinant measles vaccine vector expressing HIV-1 antigens, in cynomolgus macaques
por: Lorin, Clarisse, et al.
Publicado: (2012)

Chimpanzee adenoviral vector prime-boost regimen elicits potent immune responses against Ebola virus in mice and rhesus macaques
por: Yang, Xi, et al.
Publicado: (2019)

Increased immunogenicity of HIV vaccination with constant-current electroporation and molecular adjuvants in mice and rhesus macaques
por: Hirao, Lauren, et al.
Publicado: (2006)

Evaluation of a 15-valent Pneumococcal Conjugate Vaccine in an Adult Rhesus Macaque Immunogenicity Model
por: Xie, Jinfu, et al.
Publicado: (2017)

Hepatitis B vaccination using a dissolvable microneedle patch is immunogenic in mice and rhesus macaques
por: Perez Cuevas, Monica B., et al.
Publicado: (2018)

Safety and Immunogenicity of a 4-Component Toxoid-Based Staphylococcus aureus Vaccine in Rhesus Macaques
por: Venkatasubramaniam, Arundhathi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cpu0v8rh5lk557cotq3k9fd0r5