Influence of the Dynamically Disordered N-Terminal Tail Domain on the Amyloid Core Structure of Human Y145Stop Prion Protein Fibrils

The Y145Stop mutant of human prion protein (huPrP23-144) is associated with a familial prionopathy and provides a convenient in vitro model for investigating amyloid strains and cross-seeding barriers. huPrP23-144 fibrils feature a compact and relatively rigid parallel in-register β-sheet amyloid co...

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Detalles Bibliográficos
Autores principales: Qi, Zhe, Surewicz, Krystyna, Surewicz, Witold K., Jaroniec, Christopher P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883029/
https://www.ncbi.nlm.nih.gov/pubmed/35237664
http://dx.doi.org/10.3389/fmolb.2022.841790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883029/
https://www.ncbi.nlm.nih.gov/pubmed/35237664
http://dx.doi.org/10.3389/fmolb.2022.841790

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