Trace Level Quantification of 4-Methyl-1-nitrosopiperazin in Rifampicin Capsules by LC-MS/MS

Rifampicin is a first-line anti-tuberculosis drug. However, in August 2020, the presence of 1-methyl-4-nitrosopiperazine (MNP), a nitrosamine impurity, was detected by the United Stated Food and Drug Administration (US FDA) in rifampicin capsules. Consequently, the development of efficient methods f...

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Detalles Bibliográficos
Autores principales: Tao, Xiaosha, Tian, Ye, Liu, Wan-Hui, Yao, Shangchen, Yin, Lihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883033/
https://www.ncbi.nlm.nih.gov/pubmed/35237562
http://dx.doi.org/10.3389/fchem.2022.834124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883033/
https://www.ncbi.nlm.nih.gov/pubmed/35237562
http://dx.doi.org/10.3389/fchem.2022.834124

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