Cargando…

Trace Level Quantification of 4-Methyl-1-nitrosopiperazin in Rifampicin Capsules by LC-MS/MS

Rifampicin is a first-line anti-tuberculosis drug. However, in August 2020, the presence of 1-methyl-4-nitrosopiperazine (MNP), a nitrosamine impurity, was detected by the United Stated Food and Drug Administration (US FDA) in rifampicin capsules. Consequently, the development of efficient methods f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tao, Xiaosha, Tian, Ye, Liu, Wan-Hui, Yao, Shangchen, Yin, Lihui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883033/ https://www.ncbi.nlm.nih.gov/pubmed/35237562 http://dx.doi.org/10.3389/fchem.2022.834124

Ejemplares similares

Development and Validation of LC-MS/MS Method for the Determination of 1-Methyl-4-Nitrosopiperazine (MNP) in Multicomponent Products with Rifampicin—Analytical Challenges and Degradation Studies
por: Witkowska, Anna B., et al.
Publicado: (2023)

Fast and Simple LC-MS/MS Method for Rifampicin Quantification in Human Plasma
por: Temova Rakuša, Žane, et al.
Publicado: (2019)

Investigation of the metabolic stability of olmutinib by validated LC-MS/MS: quantification in human plasma
por: Attwa, Mohamed W., et al.
Publicado: (2018)

Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gα(q) Protein Inhibitors in Biological Samples
por: Kuschak, Markus, et al.
Publicado: (2020)

Unravelling the antifungal and antiprotozoal activities and LC-MS/MS quantification of steroidal saponins isolated from Panicum turgidum
por: Zaki, Ahmed A., et al.
Publicado: (2022)

A validated LC-MS/MS analytical method for the quantification of pemigatinib: metabolic stability evaluation in human liver microsomes
por: Attwa, Mohamed W., et al.
Publicado: (2022)

Recent Progress in FD-LC-MS/MS Proteomics Method
por: Kobayashi, Hiroshi, et al.
Publicado: (2021)

Targeted Metabolomics: The LC-MS/MS Based Quantification of the Metabolites Involved in the Methylation Biochemical Pathways
por: Ntasi, Georgia, et al.
Publicado: (2021)

Quantification of clofarabine in urine and plasma by LC-MS/MS: suitable for PK study and TDM in pediatric patients with relapsed or refractory ALL
por: Zhang, Xi, et al.
Publicado: (2022)

Stoichiometric Quantification of Akt Phosphorylation Using LC-MS/MS
por: Atrih, Abdelmadjid, et al.
Publicado: (2009)

Sapitinib: reactive intermediates and bioactivation pathways characterized by LC-MS/MS
por: Attwa, Mohamed W., et al.
Publicado: (2019)

Pipelines and Systems for Threshold-Avoiding Quantification of LC–MS/MS Data
por: Sánchez Brotons, Alejandro, et al.
Publicado: (2021)

Estimation of measurement uncertainty for the quantification of protein by ID-LC–MS/MS
por: Beasley-Green, Ashley, et al.
Publicado: (2023)

Trace analysis of emerging and regulated mycotoxins in infant stool by LC-MS/MS
por: Krausová, Magdaléna, et al.
Publicado: (2021)

A novel LC-MS/MS method combined with derivatization for simultaneous quantification of vitamin D metabolites in human serum with diabetes as well as hyperlipidemia
por: Wang, Xiaodi, et al.
Publicado: (2023)

Simultaneous quantification of apolipoproteins A-I, E, and J in human plasma by LC-MS/MS for clinical application to diabetes mellitus complicated with cardiovascular disease
por: Li, Pengfei, et al.
Publicado: (2022)

Data to support a simultaneous testosterone and estradiol assay in serum by LC-MS/MS
por: Schofield, Ryan C., et al.
Publicado: (2018)

Data in support for the measurement of heparan sulfate and dermatan sulfate by LC–MS/MS analysis
por: Forni, Giulia, et al.
Publicado: (2018)

Simultaneous Determination of RDX and HMX in Rat Plasma by LC-MS/MS and its Applications
por: Zhang, Xi, et al.
Publicado: (2022)

Click chemistry-based enrichment strategy for tracing cellular fatty acid metabolism by LC-MS/MS
por: Yang, Ru-Jie, et al.
Publicado: (2023)

New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS/MS
por: Tan, Bo, et al.
Publicado: (2017)

Quantification of cGMP in human plasma by isotope dilution LC-MS/MS
por: Martens-Lobenhoffer, Jens, et al.
Publicado: (2009)

LC-MS/MS Quantification of Tramadol and Gabapentin Utilizing Solid Phase Extraction
por: Nagaraju, Pappula, et al.
Publicado: (2018)

Modern Approaches in the Identification and Quantification of Immunogenic Peptides in Cereals by LC-MS/MS
por: Alves, Thais O., et al.
Publicado: (2019)

LC-MS/MS for Ultra-Sensitive Quantification of Multiple Estrogens in the Blood and Brain
por: Jalabert, Cecilia, et al.
Publicado: (2021)

Rapid LC-MS/MS Bosutinib Quantification with Applications in Metabolic Stability Estimation
por: Attwa, Mohamed W., et al.
Publicado: (2023)

Development, Validation, and Comparison of Two Mass Spectrometry Methods (LC-MS/HRMS and LC-MS/MS) for the Quantification of Rituximab in Human Plasma
por: Millet, Aurélien, et al.
Publicado: (2021)

Ginsenosides analysis of New Zealand–grown forest Panax ginseng by LC-QTOF-MS/MS
por: Chen, Wei, et al.
Publicado: (2020)

HAMA: a multiplexed LC-MS/MS assay for specificity profiling of adenylate-forming enzymes
por: Stanišić, Aleksa, et al.
Publicado: (2019)

Protein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS
por: Geib, Timon, et al.
Publicado: (2021)

Reactive intermediates in copanlisib metabolism identified by LC-MS/MS: phase I metabolic profiling
por: AlRabiah, Haitham, et al.
Publicado: (2019)

Monitoring diacylglycerols in biofluids by non-isotopically paired charge derivatization combined with LC-MS/MS
por: Liu, Yang-Dan, et al.
Publicado: (2022)

Semi-Automated Glycoproteomic Data Analysis of LC-MS Data Using GlycopeptideGraphMS in Process Development of Monoclonal Antibody Biologics
por: Pang, Kuin Tian, et al.
Publicado: (2021)

Pericardial fluid proteomic label-free quantification of differentially expressed proteins in ischemic heart disease patients with systolic dysfunction by nano-LC-ESI-MS/MS analysis
por: Ullah, Junaid, et al.
Publicado: (2020)

Development and Validation of an LC-MS/MS Method for the Ultra-Trace Analysis of Pacific Ciguatoxins in Fish
por: Nagae, Mika, et al.
Publicado: (2021)

Development and validation of a LC–MS/MS method for quantification of hetrombopag for pharmacokinetics study
por: Chen, Tao, et al.
Publicado: (2015)

Validated LC-MS/MS Method for the Quantification of Ponatinib in Plasma: Application to Metabolic Stability
por: Kadi, Adnan A., et al.
Publicado: (2016)

Quantification of tolvaptan in rabbit plasma by LC–MS/MS: Application to a pharmacokinetic study()
por: Moola, Kumar S., et al.
Publicado: (2015)

Identification and Quantification of Enniatins and Beauvericin in Animal Feeds and Their Ingredients by LC-QTRAP/MS/MS
por: Tolosa, Josefa, et al.
Publicado: (2019)

A Simple LC-MS/MS Method for the Quantification of PDA-66 in Human Plasma
por: Schwarz, Rico, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tga6eahrqulg3a80gk16267035