Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis

Although clozapine is a highly efficacious schizophrenia treatment, it is under-prescribed due to the risk of idiosyncratic drug-induced agranulocytosis (IDIAG). Clinical data indicate that most patients starting clozapine experience a transient immune response early in treatment and a similar respo...

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Detalles Bibliográficos
Autores principales: Sernoskie, Samantha Christine, Lobach, Alexandra R, Kato, Ryuji, Jee, Alison, Weston, Joseph Kyle, Uetrecht, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Immunotoxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883353/
https://www.ncbi.nlm.nih.gov/pubmed/34935985
http://dx.doi.org/10.1093/toxsci/kfab154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883353/
https://www.ncbi.nlm.nih.gov/pubmed/34935985
http://dx.doi.org/10.1093/toxsci/kfab154

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