Cargando…

Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis

Although clozapine is a highly efficacious schizophrenia treatment, it is under-prescribed due to the risk of idiosyncratic drug-induced agranulocytosis (IDIAG). Clinical data indicate that most patients starting clozapine experience a transient immune response early in treatment and a similar respo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sernoskie, Samantha Christine, Lobach, Alexandra R, Kato, Ryuji, Jee, Alison, Weston, Joseph Kyle, Uetrecht, Jack
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Immunotoxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883353/ https://www.ncbi.nlm.nih.gov/pubmed/34935985 http://dx.doi.org/10.1093/toxsci/kfab154

Ejemplares similares

The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis
por: Sernoskie, Samantha Christine, et al.
Publicado: (2023)

Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges
por: Jee, Alison, et al.
Publicado: (2021)

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha
por: Lu, Jingtao, et al.
Publicado: (2012)

Targets and Intracellular Signaling Mechanisms for Deoxynivalenol-Induced Ribosomal RNA Cleavage
por: He, Kaiyu, et al.
Publicado: (2012)

Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
por: Ali, Serat-E, et al.
Publicado: (2023)

Mouse innate-like B-1 lymphocytes promote inhaled particle-induced in vitro granuloma formation and inflammation in conjunction with macrophages
por: Hiéronimus, Léa, et al.
Publicado: (2021)

Role of miR-24-3p and miR-146a-5p in dendritic cells’ maturation process induced by contact sensitizers
por: Galbiati, Valentina, et al.
Publicado: (2023)

Immunological impact of graphene oxide sheets in the abdominal cavity is governed by surface reactivity
por: Rodrigues, Artur Filipe, et al.
Publicado: (2018)

An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac
por: Selvaraj, Saravanakumar, et al.
Publicado: (2020)

The GARDpotency Assay for Potency-Associated Subclassification of Chemical Skin Sensitizers—Rationale, Method Development, and Ring Trial Results of Predictive Performance and Reproducibility
por: Gradin, Robin, et al.
Publicado: (2020)

Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells
por: Chen, I-Ling, et al.
Publicado: (2020)

Characterization of the Class I MHC Peptidome Resulting From DNCB Exposure of HaCaT Cells
por: Bailey, Alistair, et al.
Publicado: (2020)

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
por: Ogese, Monday O, et al.
Publicado: (2021)

Preliminary nonclinical safety and immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs
por: Madar-Balakirski, Noa, et al.
Publicado: (2022)

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity
por: Hammond, Sean, et al.
Publicado: (2021)

Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque
por: Dai, Xuedong, et al.
Publicado: (2022)

rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits
por: Rosner, Amir, et al.
Publicado: (2022)

Electronic cigarette vapor exposure exaggerates the pro-inflammatory response during influenza A viral infection in human distal airway epithelium
por: Schaunaman, Niccolette, et al.
Publicado: (2022)

Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case–control study
por: Nakajima, Tamie, et al.
Publicado: (2022)

Influence of deoxynivalenol-contaminated feed on the immune response of pigs after PRRSV vaccination and infection
por: Pierron, Alix, et al.
Publicado: (2023)

Quantifying the impact of PFOA exposure on B-cell development and antibody production
por: Taylor, Krystal D, et al.
Publicado: (2023)

Development of an in chemico high-throughput screening method for the identification of skin sensitization potential
por: Ferreira, Isabel, et al.
Publicado: (2023)

Applicability of the DPRA on mixture testing: challenges and opportunities
por: Marcelis, Quinten, et al.
Publicado: (2023)

Clozapine-induced agranulocytosis
por: Mijovic, Aleksandar, et al.
Publicado: (2020)

Drug-Induced Idiosyncratic Agranulocytosis - Infrequent but Dangerous
por: Rattay, Bernd, et al.
Publicado: (2021)

Idiosyncratic Drug-Induced Neutropenia and Agranulocytosis in Elderly Patients
por: Lorenzo-Villalba, Noel, et al.
Publicado: (2020)

Late Onset Clozapine Induced Agranulocytosis
por: Velayudhan, Rajmohan, et al.
Publicado: (2014)

Immune mechanisms of idiosyncratic drug-induced liver injury
por: Mak, Alastair, et al.
Publicado: (2017)

CLOZAPINE-INDUCED AGRANULOCYTOSIS AND USE OF G-CSF
por: Srinivasan, T.N., et al.
Publicado: (1998)

State of Art of Idiosyncratic Drug-Induced Neutropenia or Agranulocytosis, with a Focus on Biotherapies
por: Andrès, Emmanuel, et al.
Publicado: (2019)

AGRANULOCYTOSIS DURING CLOZAPINE THERAPY
por: Jagadheesan, K., et al.
Publicado: (2000)

Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues
por: Teschke, Rolf, et al.
Publicado: (2021)

Mechanistic Studies of Idiosyncratic DILI: Clinical Implications
por: Uetrecht, Jack
Publicado: (2019)

Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis
por: Verbelen, M, et al.
Publicado: (2015)

Deferiprone‐induced agranulocytosis: 20 years of clinical observations
por: Tricta, Fernando, et al.
Publicado: (2016)

Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis
por: Islam, Farhana, et al.
Publicado: (2022)

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis
por: Numata, Shusuke, et al.
Publicado: (2018)

Idiosyncratic Drug Reactions: A 35-Year Chemical Research in Toxicology Perspective
por: Uetrecht, Jack
Publicado: (2022)

Leukopenia and agranulocytosis in atypical antipsychotic treatment - besides clozapine
por: Jorge, B., et al.
Publicado: (2021)

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
por: Goldstein, Jacqueline I, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6kg24jg19uuadfko1t5rkt3gn2