A novel model of nephrotic syndrome results from a point mutation in Lama5 and is modified by genetic background

Nephrotic syndrome is characterized by severe proteinuria, hypoalbuminaemia, edema and hyperlipidaemia. Genetic studies of nephrotic syndrome have led to the identification of proteins playing a crucial role in slit diaphragm signaling, regulation of actin cytoskeleton dynamics and cell-matrix inter...

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Detalles Bibliográficos
Autores principales: Falcone, Sara, Nicol, Thomas, Blease, Andrew, Randles, Michael J., Angus, Elizabeth, Page, Anton, Tam, Frederick W.K., Pusey, Charles D., Lennon, Rachel, Potter, Paul K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883398/
https://www.ncbi.nlm.nih.gov/pubmed/34774562
http://dx.doi.org/10.1016/j.kint.2021.10.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883398/
https://www.ncbi.nlm.nih.gov/pubmed/34774562
http://dx.doi.org/10.1016/j.kint.2021.10.031

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