Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology

[Image: see text] Compelling new support has been provided for histone deacetylase isoform 6 (HDAC6) as a common thread in the generation of the dysregulated proinflammatory and fibrotic phenotype in cystic fibrosis (CF). HDAC6 also plays a crucial role in bacterial clearance or killing as a direct...

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Autores principales: Barone, Simona, Cassese, Emilia, Alfano, Antonella Ilenia, Brindisi, Margherita, Summa, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883472/
https://www.ncbi.nlm.nih.gov/pubmed/35148101
http://dx.doi.org/10.1021/acs.jmedchem.1c02067
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author Barone, Simona
Cassese, Emilia
Alfano, Antonella Ilenia
Brindisi, Margherita
Summa, Vincenzo
author_facet Barone, Simona
Cassese, Emilia
Alfano, Antonella Ilenia
Brindisi, Margherita
Summa, Vincenzo
author_sort Barone, Simona
collection PubMed
description [Image: see text] Compelling new support has been provided for histone deacetylase isoform 6 (HDAC6) as a common thread in the generation of the dysregulated proinflammatory and fibrotic phenotype in cystic fibrosis (CF). HDAC6 also plays a crucial role in bacterial clearance or killing as a direct consequence of its effects on CF immune responses. Inhibiting HDAC6 functions thus eventually represents an innovative and effective strategy to tackle multiple aspects of CF-associated lung disease. In this Perspective, we not only showcase the latest evidence linking HDAC(6) activity and expression with CF phenotype but also track the new dawn of HDAC(6) modulators in CF and explore potentialities and future perspectives in the field.
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spelling pubmed-88834722022-03-01 Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology Barone, Simona Cassese, Emilia Alfano, Antonella Ilenia Brindisi, Margherita Summa, Vincenzo J Med Chem [Image: see text] Compelling new support has been provided for histone deacetylase isoform 6 (HDAC6) as a common thread in the generation of the dysregulated proinflammatory and fibrotic phenotype in cystic fibrosis (CF). HDAC6 also plays a crucial role in bacterial clearance or killing as a direct consequence of its effects on CF immune responses. Inhibiting HDAC6 functions thus eventually represents an innovative and effective strategy to tackle multiple aspects of CF-associated lung disease. In this Perspective, we not only showcase the latest evidence linking HDAC(6) activity and expression with CF phenotype but also track the new dawn of HDAC(6) modulators in CF and explore potentialities and future perspectives in the field. American Chemical Society 2022-02-11 2022-02-24 /pmc/articles/PMC8883472/ /pubmed/35148101 http://dx.doi.org/10.1021/acs.jmedchem.1c02067 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Barone, Simona
Cassese, Emilia
Alfano, Antonella Ilenia
Brindisi, Margherita
Summa, Vincenzo
Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology
title Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology
title_full Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology
title_fullStr Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology
title_full_unstemmed Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology
title_short Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology
title_sort chasing a breath of fresh air in cystic fibrosis (cf): therapeutic potential of selective hdac6 inhibitors to tackle multiple pathways in cf pathophysiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883472/
https://www.ncbi.nlm.nih.gov/pubmed/35148101
http://dx.doi.org/10.1021/acs.jmedchem.1c02067
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