Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish

DEAD-box Helicase 41 (DDX41) is a recently identified factor mutated in hematologic malignancies whose function in hematopoiesis is unknown. Using an in vivo model of Ddx41 deficiency, we unveiled a critical role for this helicase in regulating erythropoiesis. We demonstrated that loss of ddx41 lead...

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Detalles Bibliográficos
Autores principales: Weinreb, Joshua T., Gupta, Varun, Sharvit, Elianna, Weil, Rachel, Bowman, Teresa V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883538/
https://www.ncbi.nlm.nih.gov/pubmed/33763998
http://dx.doi.org/10.3324/haematol.2020.257246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8883538/
https://www.ncbi.nlm.nih.gov/pubmed/33763998
http://dx.doi.org/10.3324/haematol.2020.257246

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