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Tolerable upper intake level for dietary sugars

Following a request from five European Nordic countries, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was tasked to provide scientific advice on a tolerable upper intake level (UL) or a safe level of intake for dietary (total/added/free) sugars based on available data on chronic...

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Autores principales: Turck, Dominique, Bohn, Torsten, Castenmiller, Jacqueline, de Henauw, Stefaan, Hirsch‐Ernst, Karen Ildico, Knutsen, Helle Katrine, Maciuk, Alexander, Mangelsdorf, Inge, McArdle, Harry J, Naska, Androniki, Peláez, Carmen, Pentieva, Kristina, Siani, Alfonso, Thies, Frank, Tsabouri, Sophia, Adan, Roger, Emmett, Pauline, Galli, Carlo, Kersting, Mathilde, Moynihan, Paula, Tappy, Luc, Ciccolallo, Laura, de Sesmaisons‐Lecarré, Agnès, Fabiani, Lucia, Horvath, Zsuzsanna, Martino, Laura, Muñoz Guajardo, Irene, Valtueña Martínez, Silvia, Vinceti, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884083/
https://www.ncbi.nlm.nih.gov/pubmed/35251356
http://dx.doi.org/10.2903/j.efsa.2022.7074
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author Turck, Dominique
Bohn, Torsten
Castenmiller, Jacqueline
de Henauw, Stefaan
Hirsch‐Ernst, Karen Ildico
Knutsen, Helle Katrine
Maciuk, Alexander
Mangelsdorf, Inge
McArdle, Harry J
Naska, Androniki
Peláez, Carmen
Pentieva, Kristina
Siani, Alfonso
Thies, Frank
Tsabouri, Sophia
Adan, Roger
Emmett, Pauline
Galli, Carlo
Kersting, Mathilde
Moynihan, Paula
Tappy, Luc
Ciccolallo, Laura
de Sesmaisons‐Lecarré, Agnès
Fabiani, Lucia
Horvath, Zsuzsanna
Martino, Laura
Muñoz Guajardo, Irene
Valtueña Martínez, Silvia
Vinceti, Marco
author_facet Turck, Dominique
Bohn, Torsten
Castenmiller, Jacqueline
de Henauw, Stefaan
Hirsch‐Ernst, Karen Ildico
Knutsen, Helle Katrine
Maciuk, Alexander
Mangelsdorf, Inge
McArdle, Harry J
Naska, Androniki
Peláez, Carmen
Pentieva, Kristina
Siani, Alfonso
Thies, Frank
Tsabouri, Sophia
Adan, Roger
Emmett, Pauline
Galli, Carlo
Kersting, Mathilde
Moynihan, Paula
Tappy, Luc
Ciccolallo, Laura
de Sesmaisons‐Lecarré, Agnès
Fabiani, Lucia
Horvath, Zsuzsanna
Martino, Laura
Muñoz Guajardo, Irene
Valtueña Martínez, Silvia
Vinceti, Marco
collection PubMed
description Following a request from five European Nordic countries, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was tasked to provide scientific advice on a tolerable upper intake level (UL) or a safe level of intake for dietary (total/added/free) sugars based on available data on chronic metabolic diseases, pregnancy‐related endpoints and dental caries. Specific sugar types (fructose) and sources of sugars were also addressed. The intake of dietary sugars is a well‐established hazard in relation to dental caries in humans. Based on a systematic review of the literature, prospective cohort studies do not support a positive relationship between the intake of dietary sugars, in isocaloric exchange with other macronutrients, and any of the chronic metabolic diseases or pregnancy‐related endpoints assessed. Based on randomised control trials on surrogate disease endpoints, there is evidence for a positive and causal relationship between the intake of added/free sugars and risk of some chronic metabolic diseases: The level of certainty is moderate for obesity and dyslipidaemia (> 50–75% probability), low for non‐alcoholic fatty liver disease and type 2 diabetes (> 15–50% probability) and very low for hypertension (0–15% probability). Health effects of added vs. free sugars could not be compared. A level of sugars intake at which the risk of dental caries/chronic metabolic diseases is not increased could not be identified over the range of observed intakes, and thus, a UL or a safe level of intake could not be set. Based on available data and related uncertainties, the intake of added and free sugars should be as low as possible in the context of a nutritionally adequate diet. Decreasing the intake of added and free sugars would decrease the intake of total sugars to a similar extent. This opinion can assist EU Member States in setting national goals/recommendations.
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spelling pubmed-88840832022-03-04 Tolerable upper intake level for dietary sugars Turck, Dominique Bohn, Torsten Castenmiller, Jacqueline de Henauw, Stefaan Hirsch‐Ernst, Karen Ildico Knutsen, Helle Katrine Maciuk, Alexander Mangelsdorf, Inge McArdle, Harry J Naska, Androniki Peláez, Carmen Pentieva, Kristina Siani, Alfonso Thies, Frank Tsabouri, Sophia Adan, Roger Emmett, Pauline Galli, Carlo Kersting, Mathilde Moynihan, Paula Tappy, Luc Ciccolallo, Laura de Sesmaisons‐Lecarré, Agnès Fabiani, Lucia Horvath, Zsuzsanna Martino, Laura Muñoz Guajardo, Irene Valtueña Martínez, Silvia Vinceti, Marco EFSA J Scientific Opinion Following a request from five European Nordic countries, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was tasked to provide scientific advice on a tolerable upper intake level (UL) or a safe level of intake for dietary (total/added/free) sugars based on available data on chronic metabolic diseases, pregnancy‐related endpoints and dental caries. Specific sugar types (fructose) and sources of sugars were also addressed. The intake of dietary sugars is a well‐established hazard in relation to dental caries in humans. Based on a systematic review of the literature, prospective cohort studies do not support a positive relationship between the intake of dietary sugars, in isocaloric exchange with other macronutrients, and any of the chronic metabolic diseases or pregnancy‐related endpoints assessed. Based on randomised control trials on surrogate disease endpoints, there is evidence for a positive and causal relationship between the intake of added/free sugars and risk of some chronic metabolic diseases: The level of certainty is moderate for obesity and dyslipidaemia (> 50–75% probability), low for non‐alcoholic fatty liver disease and type 2 diabetes (> 15–50% probability) and very low for hypertension (0–15% probability). Health effects of added vs. free sugars could not be compared. A level of sugars intake at which the risk of dental caries/chronic metabolic diseases is not increased could not be identified over the range of observed intakes, and thus, a UL or a safe level of intake could not be set. Based on available data and related uncertainties, the intake of added and free sugars should be as low as possible in the context of a nutritionally adequate diet. Decreasing the intake of added and free sugars would decrease the intake of total sugars to a similar extent. This opinion can assist EU Member States in setting national goals/recommendations. John Wiley and Sons Inc. 2022-02-28 /pmc/articles/PMC8884083/ /pubmed/35251356 http://dx.doi.org/10.2903/j.efsa.2022.7074 Text en © 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Turck, Dominique
Bohn, Torsten
Castenmiller, Jacqueline
de Henauw, Stefaan
Hirsch‐Ernst, Karen Ildico
Knutsen, Helle Katrine
Maciuk, Alexander
Mangelsdorf, Inge
McArdle, Harry J
Naska, Androniki
Peláez, Carmen
Pentieva, Kristina
Siani, Alfonso
Thies, Frank
Tsabouri, Sophia
Adan, Roger
Emmett, Pauline
Galli, Carlo
Kersting, Mathilde
Moynihan, Paula
Tappy, Luc
Ciccolallo, Laura
de Sesmaisons‐Lecarré, Agnès
Fabiani, Lucia
Horvath, Zsuzsanna
Martino, Laura
Muñoz Guajardo, Irene
Valtueña Martínez, Silvia
Vinceti, Marco
Tolerable upper intake level for dietary sugars
title Tolerable upper intake level for dietary sugars
title_full Tolerable upper intake level for dietary sugars
title_fullStr Tolerable upper intake level for dietary sugars
title_full_unstemmed Tolerable upper intake level for dietary sugars
title_short Tolerable upper intake level for dietary sugars
title_sort tolerable upper intake level for dietary sugars
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884083/
https://www.ncbi.nlm.nih.gov/pubmed/35251356
http://dx.doi.org/10.2903/j.efsa.2022.7074
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