Cargando…

p140Cap Controls Female Fertility in Mice Acting via Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons

p140Cap, encoded by the gene SRCIN1 (SRC kinase signaling inhibitor 1), is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic mechanisms. p140Cap knock-out (KO) female mice show severe hypofertility, delayed puberty onset, altered estrus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Camera, Mattia, Russo, Isabella, Zamboni, Valentina, Ammoni, Alessandra, Rando, Simona, Morellato, Alessandro, Cimino, Irene, Angelini, Costanza, Giacobini, Paolo, Oleari, Roberto, Amoruso, Federica, Cariboni, Anna, Franceschini, Isabelle, Turco, Emilia, Defilippi, Paola, Merlo, Giorgio R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884249/ https://www.ncbi.nlm.nih.gov/pubmed/35237119 http://dx.doi.org/10.3389/fnins.2022.744693

Ejemplares similares

The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness
por: Salemme, Vincenzo, et al.
Publicado: (2020)

Dissecting the Shared and Context-Dependent Pathways Mediated by the p140Cap Adaptor Protein in Cancer and in Neurons
por: Chapelle, Jennifer, et al.
Publicado: (2019)

Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders
por: Alfieri, Annalisa, et al.
Publicado: (2017)

The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma
por: Grasso, Silvia, et al.
Publicado: (2019)

Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency
por: Oleari, Roberto, et al.
Publicado: (2023)

Peptide and Lipid Modulation of Glutamatergic Afferent Synaptic Transmission in the Solitary Tract Nucleus
por: Andresen, Michael C., et al.
Publicado: (2013)

Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human
por: Hrabovszky, Erik, et al.
Publicado: (2013)

Semaphorin Signaling in the Development and Function of the Gonadotropin Hormone-Releasing Hormone System
por: Messina, Andrea, et al.
Publicado: (2013)

Paraventricular Hypothalamic Nucleus Upregulates Intraocular Pressure Via Glutamatergic Neurons
por: Ma, Lin, et al.
Publicado: (2023)

Adenosine Downregulates the Activities of Glutamatergic Neurons in the Paraventricular Hypothalamic Nucleus Required for Sleep
por: Chen, Changlin, et al.
Publicado: (2022)

Abnormal Development of Glutamatergic Synapses Afferent to Dopaminergic Neurons of the Pink1(−/−) Mouse Model of Parkinson’s Disease
por: Pearlstein, Edouard, et al.
Publicado: (2016)

p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response
por: Salemme, Vincenzo, et al.
Publicado: (2023)

Development of the gonadotropin‐releasing hormone system
por: Duittoz, Anne H., et al.
Publicado: (2022)

The Differential Roles for Neurodevelopmental and Neuroendocrine Genes in Shaping GnRH Neuron Physiology and Deficiency
por: Oleari, Roberto, et al.
Publicado: (2021)

Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities
por: Zamboni, Valentina, et al.
Publicado: (2018)

Exploring Behavioral Correlates of Afferent Inhibition
por: Turco, Claudia V., et al.
Publicado: (2018)

Disrupted-in-Schizophrenia (DISC1) Functions Presynaptically at Glutamatergic Synapses
por: Maher, Brady J., et al.
Publicado: (2012)

Venoconstrictor responses to activation of bradykinin‐sensitive pericardial afferents involve the region of the hypothalamic paraventricular nucleus
por: Martin, Doug, et al.
Publicado: (2022)

New insights into anti-Müllerian hormone role in the hypothalamic–pituitary–gonadal axis and neuroendocrine development
por: Silva, Mauro S. B., et al.
Publicado: (2020)

Ontogenesis of Gonadotropin-Releasing Hormone Neurons: A Model for Hypothalamic Neuroendocrine Cell Development
por: Stevenson, Erica L., et al.
Publicado: (2013)

In Vitro, Ex Vivo and In Vivo Techniques to Study Neuronal Migration in the Developing Cerebral Cortex
por: Azzarelli, Roberta, et al.
Publicado: (2017)

A Novel Loss-of-Function SEMA3E Mutation in a Patient with Severe Intellectual Disability and Cognitive Regression
por: Paganoni, Alyssa J. J., et al.
Publicado: (2022)

The role of tumor microenvironment in drug resistance: emerging technologies to unravel breast cancer heterogeneity
por: Salemme, Vincenzo, et al.
Publicado: (2023)

Selective Restoration of Pomc Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network
por: Jones, Graham L., et al.
Publicado: (2019)

Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice
por: Zhao, Shiyi, et al.
Publicado: (2021)

Mapping of p140Cap Phosphorylation Sites: The EPLYA and EGLYA Motifs Have a Key Role in Tyrosine Phosphorylation and Csk Binding, and Are Substrates of the Abl Kinase
por: Repetto, Daniele, et al.
Publicado: (2013)

Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia
por: Kamitakahara, Anna, et al.
Publicado: (2015)

Zebrafish adult-derived hypothalamic neurospheres generate gonadotropin-releasing hormone (GnRH) neurons
por: Cortés-Campos, Christian, et al.
Publicado: (2015)

High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens
por: Tsai, Sheng-Feng, et al.
Publicado: (2022)

Cerebellar fastigial nucleus is involved in post-stroke depression through direct cerebellar-hypothalamic GABAergic and glutamatergic projections
por: Li, Yuan, et al.
Publicado: (2019)

The distribution and reliability of TMS-evoked short- and long-latency afferent interactions
por: Toepp, Stephen L., et al.
Publicado: (2021)

Subpopulations of neurokinin 1 receptor-expressing neurons in the rat lateral amygdala display a differential pattern of innervation from distinct glutamatergic afferents
por: Sreepathi, H.K., et al.
Publicado: (2012)

Experimental environment improves the reliability of short-latency afferent inhibition
por: Ramdeo, Karishma R., et al.
Publicado: (2023)

Regulation of Pituitary Cocaine- and Amphetamine-Regulated Transcript Expression and Secretion by Hypothalamic Gonadotropin-Releasing Hormone in Chickens
por: Mo, Chunheng, et al.
Publicado: (2019)

p130Cas/BCAR1 and p140Cap/SRCIN1 Adaptors: The Yin Yang in Breast Cancer?
por: Centonze, Giorgia, et al.
Publicado: (2021)

Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence
por: Parkash, Jyoti, et al.
Publicado: (2015)

Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells
por: Lund, Carina, et al.
Publicado: (2016)

Area-specific analysis of the distribution of hypothalamic neurons projecting to the rat ventral tegmental area, with special reference to the GABAergic and glutamatergic efferents
por: Kalló, Imre, et al.
Publicado: (2015)

Insulin-like Growth Factor 1, Growth Hormone, and Anti-Müllerian Hormone Receptors Are Differentially Expressed during GnRH Neuron Development
por: Paganoni, Alyssa J. J., et al.
Publicado: (2023)

Investigating the intra-session reliability of short and long latency afferent inhibition
por: Rehsi, Ravjot S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_15k8nkcth034iugfstg0uu8f07