Inducing I(to,f) and phase 1 repolarization of the cardiac action potential with a Kv4.3/KChIP2.1 bicistronic transgene

The fast transient outward potassium current (I(to,f)) plays a key role in phase 1 repolarization of the human cardiac action potential (AP) and its reduction in heart failure (HF) contributes to the loss of contractility. Therefore, restoring I(to,f) might be beneficial for treating HF. The coding...

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Detalles Bibliográficos
Autores principales: Wang, Nan, Dries, Eef, Fowler, Ewan D., Harmer, Stephen C., Hancox, Jules C., Cannell, Mark B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884339/
https://www.ncbi.nlm.nih.gov/pubmed/34823101
http://dx.doi.org/10.1016/j.yjmcc.2021.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884339/
https://www.ncbi.nlm.nih.gov/pubmed/34823101
http://dx.doi.org/10.1016/j.yjmcc.2021.11.004

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