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Inducing I(to,f) and phase 1 repolarization of the cardiac action potential with a Kv4.3/KChIP2.1 bicistronic transgene
The fast transient outward potassium current (I(to,f)) plays a key role in phase 1 repolarization of the human cardiac action potential (AP) and its reduction in heart failure (HF) contributes to the loss of contractility. Therefore, restoring I(to,f) might be beneficial for treating HF. The coding...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884339/ https://www.ncbi.nlm.nih.gov/pubmed/34823101 http://dx.doi.org/10.1016/j.yjmcc.2021.11.004 |