A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation

With an incidence of ~50%, the absence or reduced protein level of p53 is much more common than TP53 mutations in acute myeloid leukemia (AML). AML with FLT3-ITD (internal tandem duplication) mutations has an unfavorable prognosis and is highly associated with wt-p53 dysfunction. While TP53 mutation...

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Detalles Bibliográficos
Autores principales: Yang, Min, Pan, Zengkai, Huang, Kezhi, Büsche, Guntram, Liu, Hongyun, Göhring, Gudrun, Rumpel, Regina, Dittrich-Breiholz, Oliver, Talbot, Steven, Scherr, Michaela, Chaturvedi, Anuhar, Eder, Matthias, Skokowa, Julia, Zhou, Jianfeng, Welte, Karl, von Neuhoff, Nils, Liu, Ligen, Ganser, Arnold, Li, Zhixiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885416/
https://www.ncbi.nlm.nih.gov/pubmed/34732858
http://dx.doi.org/10.1038/s41375-021-01452-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885416/
https://www.ncbi.nlm.nih.gov/pubmed/34732858
http://dx.doi.org/10.1038/s41375-021-01452-6

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