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Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1
Biased signaling of G protein-coupled receptors describes an ability of different ligands that preferentially activate an alternative downstream signaling pathway. In this work, we identified and characterized different N-terminal truncations of endogenous chemokine CCL15 as balanced or biased agoni...
Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , |
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Μορφή: | Online Άρθρο Κείμενο |
Γλώσσα: | English |
Έκδοση: |
Nature Publishing Group US
2021
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Θέματα: | |
Διαθέσιμο Online: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885419/ https://www.ncbi.nlm.nih.gov/pubmed/34949837 http://dx.doi.org/10.1038/s41589-021-00918-z |