The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons

BACKGROUND: Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a causal event for Alzheimer’s disease (AD). Recent studies have established that loss of SORL1, as well as mutations in autosomal dominant AD genes APP and PSEN1/2, pathogenically converge by swelling early endosomes,...

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Detalles Bibliográficos
Autores principales: Mishra, Swati, Knupp, Allison, Szabo, Marcell P., Williams, Charles A., Kinoshita, Chizuru, Hailey, Dale W., Wang, Yuliang, Andersen, Olav M., Young, Jessica E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885486/
https://www.ncbi.nlm.nih.gov/pubmed/35226190
http://dx.doi.org/10.1007/s00018-022-04182-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885486/
https://www.ncbi.nlm.nih.gov/pubmed/35226190
http://dx.doi.org/10.1007/s00018-022-04182-9

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