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The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons
BACKGROUND: Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a causal event for Alzheimer’s disease (AD). Recent studies have established that loss of SORL1, as well as mutations in autosomal dominant AD genes APP and PSEN1/2, pathogenically converge by swelling early endosomes,...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885486/ https://www.ncbi.nlm.nih.gov/pubmed/35226190 http://dx.doi.org/10.1007/s00018-022-04182-9 |