SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase

Calorie restriction abates aging and cardiometabolic disease by activating metabolic signaling pathways, including nicotinamide adenine dinucleotide (NAD(+)) biosynthesis and salvage. Nicotinamide phosphoribosyltransferase (NAMPT) is rate-limiting in NAD(+) salvage, yet hepatocyte NAMPT actions duri...

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Detalles Bibliográficos
Autores principales: Higgins, Cassandra B., Mayer, Allyson L., Zhang, Yiming, Franczyk, Michael, Ballentine, Samuel, Yoshino, Jun, DeBosch, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885655/
https://www.ncbi.nlm.nih.gov/pubmed/35228549
http://dx.doi.org/10.1038/s41467-022-28717-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885655/
https://www.ncbi.nlm.nih.gov/pubmed/35228549
http://dx.doi.org/10.1038/s41467-022-28717-7

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