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SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase

Calorie restriction abates aging and cardiometabolic disease by activating metabolic signaling pathways, including nicotinamide adenine dinucleotide (NAD(+)) biosynthesis and salvage. Nicotinamide phosphoribosyltransferase (NAMPT) is rate-limiting in NAD(+) salvage, yet hepatocyte NAMPT actions duri...

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Detalles Bibliográficos
Autores principales:	Higgins, Cassandra B., Mayer, Allyson L., Zhang, Yiming, Franczyk, Michael, Ballentine, Samuel, Yoshino, Jun, DeBosch, Brian J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885655/ https://www.ncbi.nlm.nih.gov/pubmed/35228549 http://dx.doi.org/10.1038/s41467-022-28717-7

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