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Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling
Nicotinamide (NAM) shapes T cell responses but its precise molecular mechanism of action remains elusive. Here, we show that NAM impairs naive T cell effector transition but also effector T cells themselves. Although aerobic glycolysis is a hallmark of activated T cells, CD8(+) T cells exposed to NA...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886054/ https://www.ncbi.nlm.nih.gov/pubmed/35243268 http://dx.doi.org/10.1016/j.isci.2022.103932 |