Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling

Nicotinamide (NAM) shapes T cell responses but its precise molecular mechanism of action remains elusive. Here, we show that NAM impairs naive T cell effector transition but also effector T cells themselves. Although aerobic glycolysis is a hallmark of activated T cells, CD8(+) T cells exposed to NA...

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Detalles Bibliográficos
Autores principales: Agliano, Federica, Karginov, Timofey A., Ménoret, Antoine, Provatas, Anthony, Vella, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886054/
https://www.ncbi.nlm.nih.gov/pubmed/35243268
http://dx.doi.org/10.1016/j.isci.2022.103932

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