A First for Human Vaccinology: GMP Compliant Radiation Attenuation of Plasmodium falciparum Sporozoites for Production of a Vaccine Against Malaria

Ionizing radiation (UV, X-ray and ɣ) administered at an appropriate dose to pathogenic organisms can prevent replication while preserving metabolic activity. We have established the GMP process for attenuation by ionizing radiation of the Plasmodium falciparum (Pf) sporozoites (SPZ) in Sanaria(®) Pf...

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Detalles Bibliográficos
Autores principales: James, Eric R., Matheny, Steve, Overby, James, Sim, B. Kim Lee, Eappen, Abraham G., Li, Tao, Li, Ming Lin, Richie, Thomas L., Chakravarty, Sumana, Gunasekera, Anusha, Murshedkar, Tooba, Billingsley, Peter F., Hoffman, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886114/
https://www.ncbi.nlm.nih.gov/pubmed/35242146
http://dx.doi.org/10.3389/fimmu.2022.851028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886114/
https://www.ncbi.nlm.nih.gov/pubmed/35242146
http://dx.doi.org/10.3389/fimmu.2022.851028

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