Cargando…
A First for Human Vaccinology: GMP Compliant Radiation Attenuation of Plasmodium falciparum Sporozoites for Production of a Vaccine Against Malaria
Ionizing radiation (UV, X-ray and ɣ) administered at an appropriate dose to pathogenic organisms can prevent replication while preserving metabolic activity. We have established the GMP process for attenuation by ionizing radiation of the Plasmodium falciparum (Pf) sporozoites (SPZ) in Sanaria(®) Pf...
Autores principales: | James, Eric R., Matheny, Steve, Overby, James, Sim, B. Kim Lee, Eappen, Abraham G., Li, Tao, Li, Ming Lin, Richie, Thomas L., Chakravarty, Sumana, Gunasekera, Anusha, Murshedkar, Tooba, Billingsley, Peter F., Hoffman, Stephen L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886114/ https://www.ncbi.nlm.nih.gov/pubmed/35242146 http://dx.doi.org/10.3389/fimmu.2022.851028 |
Ejemplares similares
-
Transient knockdown of Anopheles stephensi LRIM1 using RNAi increases Plasmodium falciparum sporozoite salivary gland infections
por: Billingsley, Peter F., et al.
Publicado: (2021) -
Controlled Human Malaria Infections by Intradermal Injection of Cryopreserved Plasmodium falciparum Sporozoites
por: Roestenberg, Meta, et al.
Publicado: (2013) -
Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines
por: Richie, Thomas L., et al.
Publicado: (2015) -
Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection
por: Lyke, Kirsten E., et al.
Publicado: (2015) -
Is Saglin a mosquito salivary gland receptor for Plasmodium falciparum?
por: O’Brochta, David A., et al.
Publicado: (2019)