Cargando…

A First for Human Vaccinology: GMP Compliant Radiation Attenuation of Plasmodium falciparum Sporozoites for Production of a Vaccine Against Malaria

Ionizing radiation (UV, X-ray and ɣ) administered at an appropriate dose to pathogenic organisms can prevent replication while preserving metabolic activity. We have established the GMP process for attenuation by ionizing radiation of the Plasmodium falciparum (Pf) sporozoites (SPZ) in Sanaria(®) Pf...

Descripción completa

Detalles Bibliográficos
Autores principales:	James, Eric R., Matheny, Steve, Overby, James, Sim, B. Kim Lee, Eappen, Abraham G., Li, Tao, Li, Ming Lin, Richie, Thomas L., Chakravarty, Sumana, Gunasekera, Anusha, Murshedkar, Tooba, Billingsley, Peter F., Hoffman, Stephen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886114/ https://www.ncbi.nlm.nih.gov/pubmed/35242146 http://dx.doi.org/10.3389/fimmu.2022.851028

Ejemplares similares

Transient knockdown of Anopheles stephensi LRIM1 using RNAi increases Plasmodium falciparum sporozoite salivary gland infections
por: Billingsley, Peter F., et al.
Publicado: (2021)

Controlled Human Malaria Infections by Intradermal Injection of Cryopreserved Plasmodium falciparum Sporozoites
por: Roestenberg, Meta, et al.
Publicado: (2013)

Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines
por: Richie, Thomas L., et al.
Publicado: (2015)

Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection
por: Lyke, Kirsten E., et al.
Publicado: (2015)

Is Saglin a mosquito salivary gland receptor for Plasmodium falciparum?
por: O’Brochta, David A., et al.
Publicado: (2019)

Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres
por: Mordmüller, Benjamin, et al.
Publicado: (2015)

Progress with PfSPZ Vaccine, a radiation attenuated Plasmodium falciparum sporozoite vaccine
por: Billingsley, Peter, et al.
Publicado: (2014)

Successful Human Infection with P. falciparum Using Three Aseptic Anopheles stephensi Mosquitoes: A New Model for Controlled Human Malaria Infection
por: Laurens, Matthew B., et al.
Publicado: (2013)

Development of an attenuated sporozoite vaccine to prevent and eliminate Plasmodium falciparum malaria
por: Billingsley, Peter F
Publicado: (2010)

Controlled Human Malaria Infection of Tanzanians by Intradermal Injection of Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites
por: Shekalaghe, Seif, et al.
Publicado: (2014)

Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults
por: Jongo, Said A., et al.
Publicado: (2018)

Cryopreservation of Anopheles stephensi embryos
por: James, Eric R., et al.
Publicado: (2022)

Efficient infection of non-human primates with purified, cryopreserved Plasmodium knowlesi sporozoites
por: Chakravarty, Sumana, et al.
Publicado: (2022)

Safety and Differential Antibody and T-Cell Responses to the Plasmodium falciparum Sporozoite Malaria Vaccine, PfSPZ Vaccine, by Age in Tanzanian Adults, Adolescents, Children, and Infants
por: Jongo, Said A., et al.
Publicado: (2019)

Safety, Immunogenicity, and Protective Efficacy of Intradermal Immunization with Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites in Volunteers under Chloroquine Prophylaxis: A Randomized Controlled Trial
por: Bastiaens, Guido J. H., et al.
Publicado: (2016)

Controlled human malaria infections using aseptic, purified cryopreserved Plasmodium falciparum sporozoites administered by needle and syringe
por: Billingsley, Peter, et al.
Publicado: (2014)

Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection
por: Hodgson, Susanne H., et al.
Publicado: (2014)

Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers: effect of injection volume and dose on infectivity rates
por: Gómez-Pérez, Gloria P, et al.
Publicado: (2015)

Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood
por: Murphy, Sean C., et al.
Publicado: (2018)

The Development of Whole Sporozoite Vaccines for Plasmodium falciparum Malaria
por: Itsara, Leslie S., et al.
Publicado: (2018)

IMRAS—Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS
por: Sedegah, Martha, et al.
Publicado: (2021)

Plasmodium falciparum Malaria Challenge by the Bite of Aseptic Anopheles stephensi Mosquitoes: Results of a Randomized Infectivity Trial
por: Lyke, Kirsten E., et al.
Publicado: (2010)

Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa
por: Silva, Joana C., et al.
Publicado: (2022)

Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium falciparum
por: Li, Tao, et al.
Publicado: (2015)

Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period
por: McLean, Alistair R. D., et al.
Publicado: (2016)

Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites
por: Schats, Remko, et al.
Publicado: (2015)

Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence
por: Inbar, Ehud, et al.
Publicado: (2021)

Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity
por: Hickey, Bradley W., et al.
Publicado: (2016)

Efficacy, T cell activation and antibody responses in accelerated Plasmodium falciparum sporozoite chemoprophylaxis vaccine regimens
por: Ibanez, Javier, et al.
Publicado: (2022)

Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children
por: Kurtovic, Liriye, et al.
Publicado: (2018)

Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum
por: Wang, Christian W, et al.
Publicado: (2010)

Memory B-Cell and Antibody Responses Induced by Plasmodium falciparum Sporozoite Immunization
por: Nahrendorf, Wiebke, et al.
Publicado: (2014)

Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor
por: Chappel, Jonathan A, et al.
Publicado: (2004)

Kinetics of Mosquito-Injected Plasmodium Sporozoites in Mice: Fewer Sporozoites Are Injected into Sporozoite-Immunized Mice
por: Kebaier, Chahnaz, et al.
Publicado: (2009)

Quantification of wild-type and radiation attenuated Plasmodium falciparum sporozoite motility in human skin
por: Winkel, Béatrice M. F., et al.
Publicado: (2019)

Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites
por: Evert, Benjamin J., et al.
Publicado: (2021)

Whole sporozoite immunization with Plasmodium falciparum strain NF135 in a randomized trial
por: van der Boor, Saskia C., et al.
Publicado: (2023)

Adaptive clinical trials of three PfSPZ products for development of a whole sporozoite vaccine that prevents Plasmodium falciparum infection, disease and transmission
por: Hoffman, Stephen L
Publicado: (2012)

The Complement System Contributes to Functional Antibody-Mediated Responses Induced by Immunization with Plasmodium falciparum Malaria Sporozoites
por: Behet, Marije C., et al.
Publicado: (2018)

Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB(2) in malaria exposed individuals
por: Nguyen, Thanh V, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_b7jub9v2jv0q3hkho4lcgn1nhj