Cargando…

Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells

Thymopentin (TP5) is an immunomodulatory pentapeptide that has been widely used in malignancy patients with immunodeficiency due to radiotherapy and chemotherapy. Here, we propose that TP5 directly inhibits the stemness of colon cancer cells HCT116 and therefore enhances the cytotoxicity of oxalipla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Peng-Cheng, Liu, Di, Han, Zeng-Xiang, Liang, Fang, Hao, Cui-Yun, Lei, Yun-Tao, Guo, Chang-Run, Wang, Wen-Hui, Li, Xing-Hua, Yang, Xiao-Na, Li, Chang-Zhu, Yu, Ye, Fan, Ying-Zhe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886222/ https://www.ncbi.nlm.nih.gov/pubmed/35242031 http://dx.doi.org/10.3389/fphar.2022.779715

Ejemplares similares

Colon Cancer Cells Gene Expression Signature As Response to 5- Fluorouracil, Oxaliplatin, and Folinic Acid Treatment
por: Negrei, Carolina, et al.
Publicado: (2016)

Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids
por: Fiore, Donatella, et al.
Publicado: (2018)

T cell development in normal and thymopentin-treated nude mice
Publicado: (1982)

Real-World Effectiveness of Adjuvant Oxaliplatin Chemotherapy in Stage III Colon Cancer: A Controlled Interrupted Time Series Analysis
por: Huang, Wen-Kuan, et al.
Publicado: (2021)

KRAS Mutation Is a Predictor of Oxaliplatin Sensitivity in Colon Cancer Cells
por: Lin, Yu-Lin, et al.
Publicado: (2012)

Cost-Effectiveness Analysis of Capecitabine Plus Oxaliplatin Versus Gemcitabine Plus Oxaliplatin as First-Line Therapy for Advanced Biliary Tract Cancers
por: Chen, Ruijia, et al.
Publicado: (2022)

Constructing a cancer stem cell related prognostic model for predicting immune landscape and drug sensitivity in colorectal cancer
por: Chen, Jianfang, et al.
Publicado: (2023)

Population Pharmacokinetics of Caspofungin and Dosing Optimization in Children With Allogeneic Hematopoietic Stem Cell Transplantation
por: Niu, Chang-He, et al.
Publicado: (2020)

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy
por: Qin, Weiwei, et al.
Publicado: (2017)

Drug-Loaded Polymeric Nanoparticles for Cancer Stem Cell Targeting
por: Li, Binbin, et al.
Publicado: (2017)

Glioblastoma Stem-Like Cells: Characteristics, Microenvironment, and Therapy
por: Yi, Yang, et al.
Publicado: (2016)

Dragon (RGMb) induces oxaliplatin resistance in colon cancer cells
por: Shi, Ying, et al.
Publicado: (2016)

Molecular Analysis of Thymopentin Binding to HLA-DR Molecules
por: Liu, Zuojia, et al.
Publicado: (2007)

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines
por: Nannizzi, Sara, et al.
Publicado: (2009)

Investigations by Cell-Mediated Immunologic Tests and Therapeutic Trials With Thymopentin in Vaginal Mycoses
por: Mendling, Werner, et al.
Publicado: (1996)

Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma
por: Li, Ya, et al.
Publicado: (2020)

Gynecologic Cancer, Cancer Stem Cells, and Possible Targeted Therapies
por: Keyvani, Vahideh, et al.
Publicado: (2022)

Inhibition of colon cancer K-Ras(G13D) mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway
por: Qi, Yan, et al.
Publicado: (2022)

The Protective Effects of Water-Soluble Alginic Acid on the N-Terminal of Thymopentin
por: Ji, Haiyu, et al.
Publicado: (2023)

Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity
por: Wang, Ying, et al.
Publicado: (2014)

Thymopentin improves cardiac function in older patients with chronic heart failure
por: Xiaojing, Cao, et al.
Publicado: (2017)

Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction
por: Liang, Yingmin, et al.
Publicado: (2017)

Cancer Stem Cell-Exosomes, Unexposed Player in Tumorigenicity
por: Al-Sowayan, Batla S., et al.
Publicado: (2020)

The Breast Cancer Stem Cells Traits and Drug Resistance
por: Zheng, Qinghui, et al.
Publicado: (2021)

Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy
por: Wu, Yafei, et al.
Publicado: (2020)

Exosome-Based Cancer Therapy: Implication for Targeting Cancer Stem Cells
por: Wang, Jinheng, et al.
Publicado: (2017)

Preparation and Evaluation of Poly-Butylcyanoacrylate Nanoparticles for Oral Delivery of Thymopentin
por: He, Weiling, et al.
Publicado: (2008)

PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells
por: Yan, Siyuan, et al.
Publicado: (2019)

METTL3 promotes drug resistance to oxaliplatin in gastric cancer cells through DNA repair pathway
por: Wang, Yi, et al.
Publicado: (2023)

JNK and Autophagy Independently Contributed to Cytotoxicity of Arsenite combined With Tetrandrine via Modulating Cell Cycle Progression in Human Breast Cancer Cells
por: Yu, Bowen, et al.
Publicado: (2020)

Targeting Strategies for Renal Cell Carcinoma: From Renal Cancer Cells to Renal Cancer Stem Cells
por: Yuan, Zhi-xiang, et al.
Publicado: (2016)

Supercritical fluid extract of Angelica sinensis promotes the anti-colorectal cancer effect of oxaliplatin
por: Hao, Doudou, et al.
Publicado: (2022)

Jiyuan oridonin A induces differentiation of acute myeloid leukemia cells including leukemic stem-like cells
por: Li, Fahui, et al.
Publicado: (2022)

Nanomedicine-Mediated Therapies to Target Breast Cancer Stem Cells
por: He, Lili, et al.
Publicado: (2016)

Stem Cell Metabolism in Cancer and Healthy Tissues: Pyruvate in the Limelight
por: Corbet, Cyril
Publicado: (2018)

Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells
por: Jagust, Petra, et al.
Publicado: (2019)

Mesenchymal stem cells elicits Anti-PD1 immunotherapy by targeted delivery of CX3CL1
por: Liu, Jize, et al.
Publicado: (2023)

Grape seed extracts modify the outcome of oxaliplatin in colon cancer cells by interfering with cellular mechanisms of drug cytotoxicity
por: Porcelli, Letizia, et al.
Publicado: (2017)

The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells
por: Gao, Hai-Ling, et al.
Publicado: (2023)

Drug Delivery Using Nanoparticles for Cancer Stem-Like Cell Targeting
por: Lu, Bing, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_app7s8q7nlim7foot0v27a49f3